Endocrine Abstracts

Objective: Sperm cells are produced in the testes by the Sertoli cells. These cells produce Inhibin B too and they are stimulated by FSH. Can Inhibin B be a good marker of spermatogenesis? Should we use other marker (FSH?, testosterone?)Design: Prospective study.Patients: We examined 56 patients with infertility.Methods: Semen analysis and hormonal analysis was performed. Semen analysis was performed accordin...

A 66-year-old patient was diagnosed with lung cancer. In the interview, smoking for 40 years, about 20 cigarettes/day. Due to the intensifying cough, an x-ray of the chest was performed, a large tumor (12 cm) of the mediastinum and the right cavity was found. In the histopathological examination squamous cell carcinoma. Stage T4 N2 M0. Due to tumor inoperability, the patient was qualified for sequential chemo-radiotherapy. He received 3 cycles of chemotherapy (navelbin and cis...

The aim of the study was to determine mRNA expression of genes involved in steroidogenic pathways in chicken ovarian follicles by real-time PCR method.Hy-Line Brown hens (n=20), 28 weeks of age, laying regular sequences of about 20 or more eggs per clutch were used in the experiment. Birds were decapitated ~2 h after ovulation. From the ovary, white prehierarchical follicles (1–8 mm) and the three largest yellow preovulatory follicles F3&#150...

Introduction: Hyponatremia can be a life-threatening emergency. Severe hyponatremia may occur in patients with hypopituitarism and secondary adrenal insufficiency and hypothyroidism. The acute decompensation of pituitary insufficiency can also lead to accompanying rhabdomyolysis and acute renal failure (ARF).Case report: A 67-year-old woman complaining of general fatigue, dizziness, nausea, feeling cold and numbness of limbs and tongue was admitted to th...

Introduction: Rapid deterioration of health condition in patient with diagnosed neoplastic disease, especially metastatic one, requires consideration of cancer progression. However other rare severe complications can occur. In 0.6–0.7% patients with medullary thyroid cancer (MTC) the ectopic ACTH syndrome (EAS) is observed. Hereby, we present a case EAS in patient suffered from MTC.Case report: A 37-year-old man was admitted to the Department of Int...

Objective: Sperm cells are produced in the testes by the Sertoli cells. These cells produce Inhibin B and they are stimulated by FSH. Can Inhibin B be a good marker of spermatogenesis? Should we use other marker (FSH?, testosterone?)Design: Prospective study.Patients: We examined 71 patients with infertility.Methods: Semen analysis and hormonal analysis was performed. Semen analysis was performed according to...

3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase (HSD3B) is a key enzyme catalyzing an essential step in the formation of all classes of steroid hormones. Previously, we have reported the presence of androgen receptors in the fetal porcine gonads denoting the role of androgens during gonadal development. There is also growing evidence that steroid hormones modulate HSD3B expression. Thus, the aim of the present study was to determine the effect of androgen defici...

Introduction: Pheochromocytoma is usually benign neuroendocrine tumor arising from chromaffin cells. Malignant tumors which account for 5–26% mainly metastize to bones, lungs, liver, but very rarely to brain. The coexistence of pheochromocytoma with brain meningioma may hinder the diagnosis.Aim: The aim of this study is to present the case of a malignant pheochromocytoma female with brain metastases and coexisting meningioma.C...

Objective: To compare metabolic characteristics of women with different phenotype of polycystic ovary syndrome (PCOS) based on Rotterdam criteria.Materials and methods: One thousand one hundred women with PCOS, aged 17–40, were recruited. The patients were divided into four subgroups according to the phenotype of PCOS defined by Rotterdam criteria: (A): oligo- and/or anovulation (Oligo), hyperandrogenism (HA), polycystic ovaries (PCO); (B): oligo+ H...

Context: Pituitary tumor can cause infertility. It can be hormonally active adenoma (mostly prolactinoma) or hormonally inactive. Hyperprolactinemia is the most common disorder. Prolactin interferes with pulsatile secretion of the hypothalamus gonadoliberin (GnRH) and consequent pituitary gonadotropins (FSH and LH), and then leads to abnormal gonadal function. As a result, a man gets impaired spermatogenesis and endocrine function of the testicles. Infertility and reduced test...